The emergence of phox-ER stress induced immunogenic apoptosis

نویسندگان

  • Abhishek D. Garg
  • Dmitri V. Krysko
  • Peter Vandenabeele
  • Patrizia Agostinis
چکیده

Primary induction of photo-oxidative (phox)-ER stress in cancer cells evoked immunogenic apoptosis (IA) associated with pre-apoptotic emission of calreticulin and ATP, and protective antitumor immunity. This IA subroutine involved "core" functions (e.g., PERK/PI3K-based modulation of secretory trafficking) rather than "private" ones (caspase-8 and eIF2α-phosphorylation) engaged by other IA inducers.

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عنوان ژورنال:

دوره 1  شماره 

صفحات  -

تاریخ انتشار 2012